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On April 15, 2026, the FDA removed 12 peptides from “Category 2” of the 503A bulk substances list. Category 2 had been reserved for substances the FDA considered to potentially present significant safety concerns for compounding pharmacies.

Peptides are short chains of amino acids that act as signaling molecules within the body. Some peptides are FDA-approved medications, while many others remain investigational or are still being studied.

Certain peptides have gained popularity online for topics such as:

* Recovery and tissue repair

* Metabolic health

* Weight management

* Sleep

* Cognitive support

* Skin and hair health

* Longevity and wellness

Patients should be cautious about purchasing peptides online from “research use only” websites or unregulated vendors. Product quality, sterility, purity, and dosing accuracy may vary significantly.